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Image Search Results
Journal: bioRxiv
Article Title: Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus
doi: 10.1101/2023.03.07.530845
Figure Lengend Snippet: IHC antibodies
Article Snippet:
Techniques: Staining
Journal: bioRxiv
Article Title: Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus
doi: 10.1101/2023.03.07.530845
Figure Lengend Snippet: TH-Cre mice received LC infusion of AAV5-DIO-hTyr or EYFP control and were assessed for locus coeruleus (LC) neuron damage 1 week later. hTyr-induced pigment expression resulted in substantial loss of axon terminals as measured by norepinephrine transporter (NET) immunoreactivity in the dentate gyrus (DG) ( d ) and anterior cingulate cortex (ACC) ( c ), with a similar decrease in NET also present in the LC itself ( a ). Concurrent with NE fiber loss was a decrease in LC cell body number as measured by NeuroTrace Nissl immunoreactivity ( b) . Images acquired at 20X. Data shown as mean ± SEM. N=3 per group. **p<0.01, ***p<0.001, ****p<0.0001.
Article Snippet:
Techniques: Control, Expressing